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M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

Gowri Rangaswamy Gunassekaran, Sri Murugan Poongkavithai Vadevoo, Moon‐Chang Baek, Byung-Heon Lee

2021Biomaterials466 citationsDOI

Topics & Concepts

MicrovesiclesMacrophage polarizationReprogrammingCancer researchImmune systemBiologyMacrophageTumor microenvironmentCancer immunotherapyImmunotherapyExosomeReceptorCell biologyImmunologyCellIn vitromicroRNABiochemistryGeneExtracellular vesicles in diseaseImmune cells in cancerImmunotherapy and Immune Responses
M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages | Litcius