Antibacterial and Antibiofilm Photodynamic Activities of Lysozyme-Au Nanoclusters/Rose Bengal Conjugates
Ichie Okamoto, Hirofumi Miyaji, Saori Miyata, Kanako Shitomi, Tsutomu Sugaya, Natsumi Ushijima, Tsukasa Akasaka, S Enya, Satoshi Saita, Hideya Kawasaki
Abstract
biofilm formation. However, in contrast, it did not have a negative effect on the proliferation, adhesion, or spread of mammalian cells, indicating low cytotoxicity. Lys-Au NCs/RB is a novel photosensitizer with low cytotoxicity that is capable of bacterial inactivation and the suppression of biofilm formation, and could help to improve dental treatments in the future.
Topics & Concepts
Rose bengalPhotosensitizerBiofilmSinglet oxygenChemistryLysozymeCytotoxicityPhotodynamic therapyAntibacterial activityConjugatePhotochemistryNanoclustersReactive oxygen speciesBacteriaOxygenBiochemistryOrganic chemistryIn vitroBiologyMathematical analysisMathematicsGeneticsNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranostics