Metal- and additive-free TfOH catalyzed chemoselective <i>O</i>- and <i>S</i>-trifluoroethylation of oxindoles, isoindolines and thio-oxindoles
Manisha Lamba, Prasoon Raj Singh, Shubham Bhatt, Avijit Goswami
Abstract
A highly efficient and chemoselective approach has been developed for the O- and S- trifluoroethylation of oxindoles, isoindolines, and thio-oxindoles utilizing Brønsted acid catalysis under greener protocol.
Topics & Concepts
Thio-CatalysisChemistryBrønsted–Lowry acid–base theoryMetalCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisSulfur-Based Synthesis Techniques