A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
Marten Hornsveld, Femke M. Feringa, Lenno Krenning, Jeroen van den Berg, Lydia M.M. Smits, Nguyen B.T. Nguyen, Maria J. Rodríguez Colman, Tobias B. Dansen, René H. Medema, Boudewijn Burgering
Abstract
inhibitor EMI1/FBXO5 through Forkhead box O (FOXO)-mediated inhibition of its transcription factor E2F1. By doing so, FOXOs limit the time during which the replication stress checkpoint is reversible and thereby play an important role in maintaining genomic stability.
Topics & Concepts
Control of chromosome duplicationCell biologyDNA replicationDNA re-replicationG2-M DNA damage checkpointGenome instabilityEukaryotic DNA replicationCell cycleReplication factor CAnaphase-promoting complexBiologyOrigin recognition complexMitosisDNA replication factor CDT1Cell cycle checkpointLicensing factorCHEK1S phaseMinichromosome maintenanceDNA damageGeneticsDNAGeneFOXO transcription factor regulationGenetics, Aging, and Longevity in Model OrganismsMicrotubule and mitosis dynamics