Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines
K. Fabitha, Anoop Kallingal, Natalia Maciejewska, C. G. Arya, Munugala Chandrakanth, Neethu Mariam Thomas, Yupeng Li, Ramesh Gondru, Manne Munikumar, Janardhan Banothu
Abstract
Nitrogen-based heterocycles substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e, & 14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines.
Topics & Concepts
ChemistryPyranBenzotriazoleImidazoleBenzimidazolePyrazoleApoptosisTriazoleIn vitroStereochemistryCell cultureCombinatorial chemistryBiochemistryOrganic chemistryBiologyGeneticsSynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis of Organic Compounds