Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino, Jee Yun Han, Michael Miller, Rebecca Melton, Elisha Beebe, Paola Benaglio, Serina Huang, Katha Korgaonkar, Sandra Heller, Alexander Kleger, Sebastian Preißl, David U. Gorkin, Maike Sander, Kyle J. Gaulton
Topics & Concepts
EpigenomicsBiologyGenome-wide association studyDuctal cellsGeneticsChromatinEnhancerTCF7L2Transcription factorCell typeLocus (genetics)AlleleGenePancreasCellGene expressionSingle-nucleotide polymorphismGenotypeEndocrinologyDNA methylationPancreatic function and diabetesDiabetes and associated disordersDiabetes Management and Research