Copper-Catalyzed Enantioselective Reductive Cross-Coupling of Aldehydes and Imines
Atsuhisa Mitsui, Kazunori Nagao, Hirohisa Ohmiya
Abstract
A copper-catalyzed enantioselective reductive cross-coupling using aromatic aldehydes and imines, producing chiral β-amino alcohols, is described. The catalytic formation of enantioenriched chiral α-alkoxyalkylcopper(I) species from aromatic aldehydes and the subsequent reaction with imine electrophiles are attractive features of this protocol.
Topics & Concepts
ChemistryEnantioselective synthesisImineElectrophileCatalysisCopperCombinatorial chemistryOrganic chemistryStereoisomerismAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods