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Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)

João P. S. Ferreira, Hélio M. T. Albuquerque, Susana M. Cardoso, Artur M. S. Silva, Vera L. M. Silva

2021European Journal of Medicinal Chemistry89 citationsDOIOpen Access PDF

Topics & Concepts

AcetylcholinesteraseChemistryContext (archaeology)CholinergicNeuroscienceDrug discoveryAlzheimer's diseaseSenile plaquesDiseasePharmacologyDementiaComputational biologyBiochemistryEnzymePsychologyMedicineInternal medicineBiologyPaleontologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsChemical synthesis and alkaloids
Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR) | Litcius