Synthesis of Carbazoles by a Diverted Bischler–Napieralski Cascade Reaction
Matteo Faltracco, Said Ortega-Rosales, Elwin Janssen, Răzvan C. Cioc, Christophe M. L. Vande Velde, Eelco Ruijter
Abstract
An unforeseen twist in a seemingly trivial Bischler-Napieralski reaction led to the selective formation of an unexpected carbazole product. The reaction proved to be general, providing access to a range of diversely substituted carbazoles from readily available substrates. Judicious variation of substituents revealed a complex cascade mechanism comprising no less than 10 elementary steps, that could be diverted in multiple ways toward various other carbazole derivatives.
Topics & Concepts
ChemistryCarbazoleCascadeCombinatorial chemistryCascade reactionReaction conditionsOrganic chemistryCatalysisChromatographyChemical synthesis and alkaloidsCatalytic C–H Functionalization MethodsCancer therapeutics and mechanisms