An enzyme-responsive double-locked amonafide prodrug for the treatment of glioblastoma with minimal side effects
Wei Cheng, Yanli Yang, Bo Zhang, Bo Zhang, Chenwen Shao, Wei Chen, Ruimin Xia, Wenwei Sun, Xiubo Zhao, Bing Zhang, Bing Zhang, Xiangjie Luo, Tony D. James, Yong Qian
Abstract
experiments confirm the potent antiproliferative activity of AcKLP against glioblastoma cells. This work demonstrates a novel de-caging strategy to improve the selectivity and efficacy of amonafide for cancer therapy.
Topics & Concepts
ProdrugChemistryEnzymeSide effect (computer science)GlioblastomaPharmacologyCancer researchBiochemistryMedicineComputer scienceProgramming languageGlioma Diagnosis and TreatmentNanoplatforms for cancer theranosticsHistone Deacetylase Inhibitors Research