Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
Spencer C. Wei, Jacob Levine, Alexandria P. Cogdill, Yang Zhao, Nana-Ama A.S. Anang, Miles C. Andrews, Padmanee Sharma, Jing Wang, Jennifer A. Wargo, Dana Pe’er, James P. Allison
Topics & Concepts
BlockadeBiologyImmune checkpointCTLA-4Mass cytometryCancer researchPD-L1NivolumabCD8Cytotoxic T cellEffectorImmune systemMelanomaImmunologyPopulationT cellCell biologyImmunotherapyGeneticsMedicineReceptorPhenotypeIn vitroGeneEnvironmental healthCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmune cells in cancer