Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis
Gengtai Ye, Qingbin Yang, Xuetao Lei, Xianjun Zhu, Fengping Li, Jiayong He, Hao Chen, Ruoyu Ling, Haisheng Zhang, Tian Lin, Zhi-Ping Liang, Yanrui Liang, Haipeng Huang, Weihong Guo, Haijun Deng, Hao Liu, Yanfeng Hu, Jiang Yu, Guoxin Li
Abstract
This study identified that nuclear MYH9-induced CTNNB1 expression promotes GC metastasis, which could be inhibited by staurosporine, indicating a novel therapy for GC peritoneal metastasis.
Topics & Concepts
AnoikisMetastasisTranscription factorCancer researchCancerCancer cellMedicineBiologyPathologyInternal medicineOncologyGeneGeneticsPeptidase Inhibition and AnalysisCancer-related gene regulationGalectins and Cancer Biology