Role of the microbiota-gut-brain axis in postacute COVID syndrome
Mélanie G. Gareau, Kim E. Barrett
2023American Journal of Physiology-Gastrointestinal and Liver Physiology22 citationsDOIOpen Access PDF
Abstract
The COVID-19 pandemic has resulted in the infection of hundreds of millions of individuals over the past 3 years, coupled with millions of deaths. Along with these more acute impacts of infection, a large subset of patients has developed symptoms that collectively comprise "postacute sequelae of COVID-19" (PASC, also known as long COVID), which can persist for months and maybe even years. In this review, we outline the current knowledge on the role of impaired microbiota-gut-brain (MGB) axis signaling in the development of PASC and the potential mechanisms involved, which may lead to a better understanding of disease progression and treatment options in the future.
Topics & Concepts
Gut–brain axisCoronavirus disease 2019 (COVID-19)Gut flora2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)NeuroscienceBiologyMedicineVirologyImmunologyPathologyDiseaseOutbreakInfectious disease (medical specialty)Long-Term Effects of COVID-19Vagus Nerve Stimulation ResearchTryptophan and brain disorders