Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells
Jae Hyeon Park, Amit Kundu, Su Hyun Lee, Chunxue Jiang, Song Hee Lee, Ye Seul Kim, So Young Kyung, So Hyun Park, Hyung Sik Kim
Abstract
xenograft model. Our findings suggest that the inhibition of PKM2 by compound 3K affected the Warburg effect and induced autophagic cell death. Therefore, use of specific PKM2 inhibitors to block the glycolytic pathway and target cancer cell metabolism represents a promising therapeutic approach for treating PKM2-overexpressing ovarian cancer.
Topics & Concepts
PKM2Cancer researchAutophagyOvarian cancerProgrammed cell deathPyruvate kinaseGlycolysisAMPKApoptosisCancer cellCancerCell growthWarburg effectKinaseBiologyChemistryMedicineCell biologyProtein kinase AInternal medicineEndocrinologyBiochemistryMetabolismAutophagy in Disease and TherapyCancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation