Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion
Si Liu, Hongbin Chen, Juan Chen, Tianyi Wang, Shangyu Tu, Xiaoyang Zhang, Qi Wang, Yuyao Yin, Yawei Zhang, Xiaojuan Wang, Chunjiang Zhao, Hui Wang
Abstract
and provided transcriptomic and proteomic profiles of normal strains and SCVs. Based on our analysis, glycolysis upregulation and TCA cycle downregulation affected the electron transport chain and energy supply, leading to slower metabolism. Moreover, capsular biosynthesis was increased, while the number of surface proteins decreased, thus promoting immune evasion by SCVs.
Topics & Concepts
TranscriptomeEvasion (ethics)ProteomeStaphylococcus aureusBiologyMicrobiologyImmune systemMethicillin-resistant Staphylococcus aureusComputational biologyGeneGeneticsBacteriaGene expressionAntimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyBacteriophages and microbial interactions