Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies
Özcan Güleç, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Büşra Dinçer, Abdulilah Ece, Ömer İrfan Küfrevioğlu, Şükrü Beydemir
Topics & Concepts
Aldose reductaseChemistryAldehyde ReductaseCytotoxicityPolyol pathwayDiabetic retinopathyCataractsAldose reductase inhibitorPharmacologyNephropathyDiabetes mellitusDiabetic nephropathyBiochemistryEnzymeIn vitroMedicineEndocrinologyOphthalmologyAldose Reductase and TaurineSynthesis and Catalytic ReactionsEicosanoids and Hypertension Pharmacology