Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-<i>d</i>]pyrimidines targeting VEGFR-2
Souad A. El‐Metwally, Hazem Elkady, Mohamed Hagras, Dalal Z. Husein, Ibrahim M. Ibrahim, Mohammed S. Taghour, Hesham A. El‐Mahdy, Ahmed Ismail, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly, Ibrahim H. Eissa
Abstract
]pyrimidine derivatives as a new class of anticancer agents and provides a foundation for further research in this area.
Topics & Concepts
PyrimidineDocking (animal)ChemistryMolecular dynamicsApoptosisCell cycleIn vitroIC50Cancer cellStereochemistryCell cycle checkpointCancer researchBiophysicsBiochemistryCancerBiologyComputational chemistryGeneticsMedicineNursingBioactive Compounds and Antitumor AgentsSynthesis and biological activityCancer Mechanisms and Therapy