Compartmentalization of Melanin Biosynthetic Enzymes Contributes to Self-Defense against Intermediate Compound Scytalone in <i>Botrytis cinerea</i>
Chen Xue, Chuanxi Zhu, Yantao Na, Dandan Ren, Chenghua Zhang, Yifan He, Yiwen Wang, Sheng Xiang, Weiheng Ren, Yina Jiang, Ling Xu, Pinkuan Zhu
Abstract
suggested two-stage partitioning of the melanogenesis pathway: the intracellular stage involves the steps until the intermediate scytalone was translocated to the cell surface, whereas the extracellular stage comprises all the steps occurring in the wall from scytalone to final melanin formation. These strategies make the fungus avert self-poisoning during melanin production. This study opens avenues for better understanding the mechanisms of secondary metabolite production in filamentous fungi.
Topics & Concepts
Botrytis cinereaMelaninMutantCompartmentalization (fire protection)BiologyFungusEnzymePathogenic fungusCell wallMyceliumMicrobiologyBiochemistrySpore germinationConidiumCell biologyGeneBotanySporePlant Pathogens and Fungal DiseasesFungal and yeast genetics researchMycotoxins in Agriculture and Food