Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B
Abdelsattar M. Omar, Mohamed Alswah, Hany E. A. Ahmed, Ashraf H. Bayoumi, Kamal M. El‐Gamal, Ahmed El-morsy, Adel Ghiaty, Tarek H. Afifi, Farag F. Sherbiny, Adel Saad Mohammed, Basem Mansour
Topics & Concepts
DNA gyraseChemistryQuinoxalineLinkerDocking (animal)AntimicrobialCombinatorial chemistryStereochemistryChalconeLead compoundDrug discoveryEscherichia coliBiochemistryIn vitroOrganic chemistryGeneNursingComputer scienceOperating systemMedicineSynthesis and Biological EvaluationSynthesis and biological activityCancer therapeutics and mechanisms