Dual Palladium-Photoredox-Mediated Regioselective Acylation of Carbazoles and Indolines
Muhammad Shahid, A. J. Punnya, Sakamuri Sarath Babu, Subhendu Sarkar, Purushothaman Gopinath
Abstract
We have described a dual palladium-photoredox-catalyzed highly regioselective acylation of carbazoles and indolines using molecular oxygen as the green oxidant. The reaction shows a broad substrate scope and good functional group tolerance. Late-stage functionalization of a carprofen drug derivative, further manipulation of products, and gram-scale synthesis of the acylated products were illustrated to show the versatility of the method.
Topics & Concepts
RegioselectivityAcylationFunctional groupPalladiumChemistryCombinatorial chemistrySubstrate (aquarium)CatalysisDerivative (finance)Organic chemistryFinancial economicsPolymerOceanographyEconomicsGeologyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques