17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation
Renlei Yang, Jie Li, Jing Zhang, Qi Xue, Ran Qin, Rong Wang, David Goltzman, Dengshun Miao
Topics & Concepts
Downregulation and upregulationOxidative stressChemistryEstrogenEndocrinologyEstrogen receptorInternal medicineOsteoporosisKEAP1OsteoblastCell biologyEstrogen receptor alphaBiologyTranscription factorMedicineIn vitroBiochemistryCancerBreast cancerGeneGenomics, phytochemicals, and oxidative stressEstrogen and related hormone effectsEndometriosis Research and Treatment