Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects
Yao Zha, Yawu Li, Tianyi Lin, Jia Chen, Shengmin Zhang, Jianglin Wang
Abstract
In our current work, we designed specifically engineered exosomes based on the requirements of vascularized bone repair in segmental bone defects. This work simultaneously illuminates the potential of functional exosomes in acellular tissue engineering.
Topics & Concepts
MicrovesiclesCell biologyExosomeAngiogenesisMesenchymal stem cellExtracellular matrixRegeneration (biology)Tissue engineeringRegenerative medicineProgenitor cellChemistryStem cellBiomedical engineeringCancer researchBiologymicroRNAMedicineGeneBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery