X‐Ray‐triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization
Zhen Du, Xin Wang, Xiao Zhang, Zhanjun Gu, Xiaoyi Fu, Shaoju Gan, Ting Fu, Sitao Xie, Weihong Tan
Abstract
Abstract Carbon monoxide (CO) is an endogenous signaling molecule with broad therapeutic effects. Here, a multifunctional X‐ray‐triggered carbon monoxide (CO) and manganese dioxide (MnO 2 ) generation nanoplatform based on metal carbonyl and scintillating nanoparticles (SCNPs) is reported. Attributed to the radioluminescent characteristic of SCNPs, UV‐responsive Mn 2 (CO) 10 is not only indirectly activated to release CO by X‐ray but can also be degraded into MnO 2 . A high dose of CO can be used as a glycolytic inhibitor for tumor suppression; it will also sensitize tumor cells to radiotherapy. Meanwhile MnO 2 , as the photolytic byproduct of Mn 2 (CO) 10 , has both glutathione (GSH) depletion and Fenton‐like Mn 2+ delivery properties to produce highly toxic hydroxyl radical (⋅OH) in tumors. Thus, this strategy can realize X‐ray‐activated CO release, GSH depletion, and ⋅OH generation for cascade cancer radiosensitization. Furthermore, X‐ray‐activated Mn 2+ in vivo demonstrates an MRI contrast effect, making it a potential theranostic nanoplatform.