Benzo[<i>d</i>]thiazole-2-thiol bearing 2-oxo-2-substituted-phenylethan-1-yl as potent selective<i>lasB</i>quorum sensing inhibitors of Gram-negative bacteria
Trương Thanh Tùng, Huy Luong Xuan, Thang Nguyen Quoc
Abstract
system with better affinity compared to reference compounds 4-NPO. Finally, computation calculations suggest that compounds are a good template for further drug development.
Topics & Concepts
ThiazoleQuorum sensingChemistryThiolStereochemistryGramBacteriaCombinatorial chemistryOrganic chemistryBiochemistryBiologyGeneGeneticsVirulenceBacterial biofilms and quorum sensingBacillus and Francisella bacterial researchAntimicrobial Peptides and Activities