Glucose Induces Resistance to Polymyxins in High-Alcohol-Producing Klebsiella pneumoniae via Increasing Capsular Polysaccharide and Maintaining Intracellular ATP
Zheng Fan, Tongtong Fu, Hongbo Liu, Zhoufei Li, Bing Du, Xiaohu Cui, Rui Zhang, Yanling Feng, Hanqing Zhao, Guanhua Xue, Jinghua Cui, Chao Yan, Lin Gan, Junxia Feng, Ziying Xu, Zihui Yu, Ziyan Tian, Zanbo Ding, Jinfeng Chen, Yujie Chen, Jing Yuan
Abstract
infection. Further research revealed the important roles of glucose and the global regulator, CRP, in bacterial resistance and found that inhibiting CPS formation and decreasing intracellular ATP levels could effectively reverse glucose-induced polymyxins resistance. Our work reveals that glucose and the regulatory factor CRP can affect the resistance of bacteria to polymyxins, laying a foundation for the treatment of infections caused by multidrug-resistant bacteria.
Topics & Concepts
PolymyxinMicrobiologyKlebsiella pneumoniaeAntibioticsBiologyDrug resistancePharmacologyChemistryBiochemistryEscherichia coliGeneAntibiotic Resistance in BacteriaVibrio bacteria research studiesAntibiotics Pharmacokinetics and Efficacy