Involvement of PTEN and FOXO3a Proteins in the Protective Activity of Protocatechuic Acid Against Cisplatin-Induced Ovarian Toxicity in Mice
B.B. Gouveia, Ricássio de Sousa Barberino, Regina Lúcia dos Santos Silva, T.L.B.G. Lins, Valéria da Silva Guimarães, Alane Pains Oliveira do Monte, Raimundo C. Palheta, M.H.T. Matos
Topics & Concepts
CisplatinGlutathionePTENApoptosisToxicityChemistryIntraperitoneal injectionReactive oxygen speciesPharmacologyAcetylcysteineSalineProliferating cell nuclear antigenCell growthAntioxidantEndocrinologyInternal medicineBiochemistryBiologyMedicineChemotherapyPI3K/AKT/mTOR pathwayEnzymeOrganic chemistryChemotherapy-induced organ toxicity mitigationReproductive Biology and Fertility