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The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Brian M. Ortmann, Natalie Burrows, Ian Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise Jordon, Olivia Lombardi, Ana Peñalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan

2021Nature Genetics84 citationsDOIOpen Access PDF

Topics & Concepts

BiologyHistoneHistone methyltransferaseChromatinEpigeneticsChromatin immunoprecipitationHistone H3GeneTranscription factorChromatin remodelingRegulation of gene expressionAcetylationMethyltransferaseHistone methylationCell biologyGene expressionMethylationDNA methylationPromoterGeneticsCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationRNA modifications and cancer
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes | Litcius