Increased c-di-GMP Levels Lead to the Production of Alginates of High Molecular Mass in Azotobacter vinelandii
Carlos L. Ahumada-Manuel, Iliana C. Martínez-Ortíz, Brian Y. Hsueh, Josefina Guzmán, Christopher M. Waters, David Zamorano‐Sánchez, Guadalupe Espı́n, Cinthia Núñez
Abstract
c-di-GMP has been widely recognized for its essential role in the production of exopolysaccharides in bacteria, such as alginate produced by Pseudomonas and Azotobacter spp. This study reveals that the levels of c-di-GMP also affect the physical properties of alginate, favoring the production of high-molecular-mass alginates in response to lower OTRs. This finding opens up new alternatives for the design of tailor-made alginates for biotechnological applications.
Topics & Concepts
Azotobacter vinelandiiMolecular massAzotobacteraceaeBiologyBiochemistryHAMPBiophysicsBacteriaEnzymeGeneticsNitrogen fixationImmunologyNitrogenaseHepcidinInflammationBacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesCarbohydrate Chemistry and Synthesis