The Role of the Gut Microbiome in Psychiatric Disorders
Ioana-Maria Andrioaie, Alexandru Duhaniuc, Eduard Vasile Năstase, Luminița Smaranda Iancu, Cătălina Luncă, Felicia Trofin, Dana-Teodora Anton-Păduraru, Olivia Dorneanu
Abstract
The role of the gut microbiome in mental health has been of great interest in the past years, with several breakthroughs happening in the last decade. Its implications in several psychiatric disorders, namely anxiety, depression, autism and schizophrenia, are highlighted. In this review were included relevant studies on rodents, as well as human studies. There seems to be a connection between the gut microbiome and these pathologies, the link being emphasized both in rodents and humans. The results obtained in murine models align with the results acquired from patients; however, fewer studies regarding anxiety were conducted on humans. The process of sequencing and analyzing the microbiome has been conducted in humans for several other pathologies mentioned above. Additionally, the possible beneficial role of probiotics and postbiotics administered as an aid to the psychiatric medication was analyzed.