Biomimetic Structure Hydrogel Loaded with Long‐Term Storage Platelet‐Rich Plasma in Diabetic Wound Repair
Neng Ding, Xinxin Fu, Qixiang Gui, Minjuan Wu, Zhongpu Niu, Antong Du, Jinyue Liu, Haimei Wu, Yue Wang, Xuezheng Yue, Lie Zhu
Abstract
Exploring the preparation of multifunctional hydrogels from a bionic perspective is an appealing strategy. Here, a multifunctional hydrogel dressing inspired by the characteristics of porous extracellular matrix produced during Acomys wound healing is prepared. These dressings are printed by digital light processing printing of hydrogels composed of gelatin methacrylate, hyaluronic acid methacrylate, and pretreated platelet-rich plasma (PRP) to shape out triply periodic minimal surface structures, which are freeze-dried for long-term storage. These dressings mimic the porous extracellular matrix of Acomys, while the freeze-drying technique effectively extends the storage duration of PRP viability. Through in vivo and in vitro experiments, the biomimetic dressings developed in this study modulate cell behavior and facilitate wound healing. Consequently, this research offers a novel approach for the advancement of regenerative wound dressings.