A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders
Ka Yang, Yu Zhao, Xueqing Nie, Hao Wu, Bo Wang, Chelsi M. Almodóvar‐Rivera, Haibo Xie, Weiping Tang
Topics & Concepts
Ubiquitin ligaseCereblonIdentification (biology)UbiquitinDNA ligaseChemistryBiologyComputational biologyBiochemistryDNAEcologyGeneProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways