Maladaptation of renal hemodynamics contributes to kidney dysfunction resulting from thoracic spinal cord injury in mice
Patrick Osei‐Owusu, Eileen Collyer, Shelby Dahlen, Raisa E. Adams, Veronica J. Tom
Abstract
Urinary complications resulting from thoracic spinal cord injury (SCI) greatly affects quality of life and contributes to morbidity and mortality in patients with SCI. Herein, we showed that thoracic SCI initiates changes in the structure and function of the renal microvasculature that leads to autoregulation failure in the chronic phase of high thoracic-level injury. Our study identified extracellular matrix regulators and cytokine/chemokine signaling as potential targets for developing novel therapeutics for restoring renal function following SCI.
Topics & Concepts
MedicineSpinal cord injuryAcute kidney injuryMaladaptationSpinal cordRenal functionUrinary systemKidneySepsisHemodynamicsAnesthesiaInternal medicinePsychiatrySpinal Cord Injury ResearchNeuroscience of respiration and sleepAcute Kidney Injury Research