Synthesis of Nonclassical Heteroaryl C-Glycosides via Decarboxylative C–H Glycosylation
Cuimei Zhang, Dongqin He, Zhaohui Ma, Mi Wang, Yafei Zhu, Yan Liu, Jian Chen, Li Guo, Guanghui Lv, Yong Wu
Abstract
A photoredox-promoted decarboxylative C-H glycosylation for the synthesis of nonclassical heteroaryl C-glycosides is reported. This methodology is characterized by an exceedingly simple reaction system, high diastereoselectivity, and good functional group tolerance. Moreover, the operational procedure is simple, and the gram-scale reaction highlights the practical applicability of this protocol.
Topics & Concepts
ChemistryGlycosylationGlycosideStereochemistryOrganic chemistryBiochemistryCarbohydrate Chemistry and SynthesisFluorine in Organic ChemistryChemical Synthesis and Analysis