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RNA-seq combined network pharmacology reveals that Fu-Gan-Wan (FGW) inhibits liver fibrosis via NF-κB/CCL2/CCR2 and lipid peroxidation via Nrf2/HMOX1 signaling pathway

Hanlin Shi, Xiaohong Duan, Jingcheng Dong, Yanyan Tao, Lei Yang

2024Journal of Ethnopharmacology15 citationsDOI

Topics & Concepts

CTGFFibrosisHepatic stellate cellSignal transductionPharmacologyCirrhosisCancer researchDownregulation and upregulationHMOX1Hepatic fibrosisSteatohepatitisMedicineChemistryBiologyFatty liverEndocrinologyCell biologyInternal medicineBiochemistryReceptorHeme oxygenaseGrowth factorDiseaseHemeEnzymeGeneLiver physiology and pathologyLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection
RNA-seq combined network pharmacology reveals that Fu-Gan-Wan (FGW) inhibits liver fibrosis via NF-κB/CCL2/CCR2 and lipid peroxidation via Nrf2/HMOX1 signaling pathway | Litcius