<scp>l</scp>-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes
Cecília Zorzi Bueno, Alexsandra Conceição Apolinário, Aroa Duro‐Castaño, Alessandro Poma, Adalberto Pessoa, Carlota de Oliveira Rangel‐Yagui, Giuseppe Battaglia
Abstract
asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze l-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on l-asparaginase.
Topics & Concepts
PolymersomeEncapsulation (networking)Materials scienceNanotechnologyChemistryPolymerComputer scienceCopolymerAmphiphileComposite materialComputer securityNanoparticle-Based Drug DeliveryClick Chemistry and ApplicationsInnovative Microfluidic and Catalytic Techniques Innovation