Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma
Wenjuan Ma, Yanling Wang, Rongxin Zhang, Fan Yang, Duo Zhang, Menggui Huang, Lin Zhang, Jay F. Dorsey, Zev A. Binder, Donald M. O’Rourke, Joseph A. Fraietta, Yanqing Gong, Yi Fan
Topics & Concepts
Tumor microenvironmentCancer researchImmunotherapyReprogrammingCancer immunotherapyChimeric antigen receptorCell biologyBiologyAngiogenesisImmune systemImmunologyCellTumor cellsGeneticsGlioma Diagnosis and TreatmentSingle-cell and spatial transcriptomicsImmune cells in cancer