Identification of a Chromosomal Integrated DNA Fragment Containing the <i>rmpA2</i> and <i>iucABCDiutA</i> Virulence Genes in Klebsiella pneumoniae
Xuemei Yang, Lianwei Ye, Li Yi, Edward Wai‐Chi Chan, Rong Zhang, Sheng Chen
Abstract
This study reported for the first time and characterized in detail the genetic features of a mobile virulence-encoding fragment located in the chromosome of a clinical virulent K. pneumoniae strain and revealed the occurrence of a transposition event mediated by IS 26 . This genetic structure could mediate the transposition of the virulence-encoding fragment into various plasmid backbones and chromosomes through formation of a circular intermediate.
Topics & Concepts
VirulenceTransposition (logic)PlasmidKlebsiella pneumoniaeBiologyGeneticsGeneChromosomeDNACircular bacterial chromosomeGenomeEscherichia coliLinguisticsPhilosophyAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsBacterial Genetics and Biotechnology