Direct Cu-mediated aromatic <sup>18</sup> F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging
Rocío García‐Vázquez, Umberto Maria Battisti, Jesper Tranekjær Jørgensen, Vladimir Shalgunov, Lars Hvass, Daniel L. Stares, Ida Nymann Petersen, François Crestey, Andreas Löffler, Dennis Svatunek, Jesper L. Kristensen, Hannes Mikula, Andreas Kjær, Matthias M. Herth
Abstract
and a radiochemical purity of >99%. Further evaluation showed that the tracer displayed favorable characteristics (target-to-background ratios and clearance) that may qualify it for future clinical translation.
Topics & Concepts
Bioorthogonal chemistryChemistryPet imagingNuclear imagingRadiochemistryPositron emission tomographyCombinatorial chemistryNuclear medicineClick chemistryMedicineClick Chemistry and ApplicationsChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research