Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior
Sing Yee Yeung, Yulia Sergeeva, Guoqing Pan, Silvia Mittler, Thomas Ederth, Tommy Dam, Peter Jönsson, Zahra El-Schich, Anette Gjörloff Wingren, Adam Tillo, Sabrina Hsiung Mattisson, Bo Holmqvist, Maria M. Stollenwerk, Börje Sellergren
Abstract
- and ω-(GRGDS)-, α-benzamidino bolaamphiphiles. Cell shape and morphology were influenced by the strength of the interactions between the amidine-functionalized amphiphiles and the oxoacid of the underlying SAMs. Dynamic control over surface composition, achieved by the addition of inert filler amphiphiles to the RGD-functionalized rSAMs, reversed the cell adhesion process. In summary, rSAMs featuring mobile bioactive ligands offer unique capabilities to influence and control cell adhesion behavior, suggesting a broad use in biomaterial design, tissue engineering, and regenerative medicine.