The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer
Christiana Magkrioti, Eleanna Kaffe, Vassilis Aidinis
Abstract
Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a secreted enzyme with lysophospholipase D activity, with its primary function being the extracellular hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid [...].
Topics & Concepts
AutotaxinLysophosphatidic acidLysophosphatidylcholinePhosphodiesteraseLysophospholipaseBiochemistryExtracellularChemistryEnzymePathophysiologyLipid signalingCell biologyBiologyPhospholipidEndocrinologyPhospholipaseReceptorPhosphatidylcholineMembraneSphingolipid Metabolism and SignalingEndoplasmic Reticulum Stress and DiseaseATP Synthase and ATPases Research