Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers
Soumik Barman, Francesco Borriello, Byron Brook, Carlo Pietrasanta, Maria De Leon, Cali Sweitzer, Manisha Menon, Simon D. van Haren, Dheeraj Soni, Yoshine Saito, Etsuro Nanishi, Sijia Yi, Sharan Bobbala, Ofer Levy, Evan A. Scott, David J. Dowling
Abstract
) cells, and germinal center (GC) B cells along with the IgG2c-skewed humoral response in vivo. Dual-loaded cGAMP/CL075-PSs did not outperform admixed cGAMP-PS and CL075-PS in vivo. These data validate an optimally designed adjuvantation system via age-selected small-molecule synergy and a multicomponent nanocarrier formulation as an effective approach to induce type 1 immune responses in early life.
Topics & Concepts
NanocarriersIn vivoImmune systemImmunizationVaccinationAgonistGerminal centerDendritic cellBiologyImmunologyCell biologyPharmacologyB cellAntibodyReceptorBiochemistryDrugBiotechnologyImmunotherapy and Immune ResponsesImmune Response and Inflammationinterferon and immune responses