Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ <sub>42</sub> oligomers by controlling their interactions with cell membranes
Zhengxin Yu, Weijie Guo, Shrey Patel, Hong‐Jun Cho, Liang Sun, Liviu M. Mirica
Abstract
-Aβ induced toxicity in cell viability assays. In addition, confocal fluorescence imaging studies provide evidence that two compounds, ZY-15-MT and ZY-15-OMe, can disrupt the interactions between Aβ oligomers and human neuroblastoma SH-SY5Y cell membranes. Overall, these studies strongly suggest that developing compounds with amphiphilic properties that target Aβ oligomers and modulate the Aβ oligomer-cell membrane interactions can be an effective strategy for the development of small molecule AD therapeutics.
Topics & Concepts
AmphiphileMembraneNeurotoxicityChemistryCellCombinatorial chemistryBiophysicsOrganic chemistryBiochemistryToxicityCopolymerPolymerBiologyAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsNeuroscience and Neuropharmacology Research