A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2)
Ingrid Fátima Zattoni, Thales Kronenberger, Diogo Henrique Kita, Laís Danciguer Guanaes, Matheus Murmel Guimarães, Larissa de Oliveira Prado, Melanie Ziasch, Luis C. Vesga, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Marcos Brown Gonçalves, Miguel D. Noseda, Diogo R.B. Ducatti, Antti Poso, Robert W. Robey, Suresh V. Ambudkar, Vivian Rotuno Moure, Alan G. Gonçalves, Gláucio Valdameri
Topics & Concepts
Abcg2Pheophorbide APorphyrinChemistryMultiple drug resistanceATP-binding cassette transporterTransporterEffluxPhotodynamic therapyAllosteric regulationIC50BiochemistryPharmacologyP-glycoproteinIn vitroBiologyEnzymeOrganic chemistryGeneAntibioticsDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsRNA Interference and Gene Delivery