Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy
Iram Khan Iqbal, Sapna Bajeli, Shivani Sahu, Shabir Ahmad Bhat, Ashwani Kumar
Abstract
; MTOR: mechanistic target of rapamycin kinase; MOI: multiplicity of infection; NO: nitric oxide; PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase; PLA: proximity ligation assay; PRKAA: protein kinase, AMP-activated, alpha catalytic subunit; SIAH1: siah E3 ubiquitin protein ligase 1A; SIRT1: sirtuin 1; TB: tuberculosis; TP53INP2/DOR: transformation related protein 53 inducible nuclear protein 2; TRP53/TP53: transformation related protein 53.
Topics & Concepts
AutophagyBiologyHydrogen sulfideGlyceraldehyde 3-phosphate dehydrogenaseCell biologyBiochemistryEnzymeApoptosisSulfurChemistryDehydrogenaseOrganic chemistryAutophagy in Disease and TherapySulfur Compounds in BiologyHeme Oxygenase-1 and Carbon Monoxide