Frequency and spectrum of founder and non-founder BRCA1 and BRCA2 mutations in a large series of Russian breast cancer and ovarian cancer patients
Anna P. Sokolenko, Tatiana N. Sokolova, E. Imyanitov, Elena V. Preobrazhenskaya, Aglaya G. Iyevleva, Svetlana N. Aleksakhina, Alexandr A. Romanko, Alexandr A. Bessonov, Tatiana V. Gorodnova, Elena I. Anisimova, E. Savonevich, Ilya V. Bizin, Ilya A. Stepanov, Petr Krivorotko, И. В. Берлев, А. М. Belyaev, Alexandr V. Togo, Evgeny N. Imyanitov
Topics & Concepts
Founder effectOvarian cancerBreast cancerLoss of heterozygosityMedicineCancerBRCA2 ProteinMutationAlleleOncologyInternal medicineGeneticsBiologyGermline mutationHaplotypeGeneBRCA gene mutations in cancerPARP inhibition in cancer therapyOvarian cancer diagnosis and treatment