Construction of a chiral artificial enzyme used for enantioselective catalysis in live cells
Ya Zhou, Weili Wei, Fengchao Cui, Zhengqing Yan, Yuhuan Sun, Jinsong Ren, Xiaogang Qu
Abstract
A yolk–shell stereoselective nanozyme is designed with a chiral selector. Nanozyme with D-/L-tryptophan possesses high selectivity towards D-/L-tyrosinol and can catalyze chiral tyrosinol to selectively label live yeast cells.
Topics & Concepts
Artificial enzymeEnantiopure drugChemistryEnantioselective synthesisKinetic resolutionCombinatorial chemistrySelectivityCatalysisPeroxidaseHorseradish peroxidaseEnantiomerDirected evolutionEnzymeStereochemistryOrganic chemistryBiochemistryGeneMutantAdvanced Nanomaterials in CatalysisNanocluster Synthesis and ApplicationsElectrochemical sensors and biosensors