Bone marrow dendritic cell aggregates associate with systemic immune dysregulation in chronic myelomonocytic leukemia
Abhishek A. Mangaonkar, Kaaren K. Reichard, Moritz Binder, Giacomo Coltro, Terra L. Lasho, Ryan M. Carr, April Chiu, Vivian Negron, Mehrdad Hefazi, Theodora Anagnostou, Michael Timm, James W. Hiebert, José C. Villasboas, Wilson I. Gonsalves, Naseema Gangat, Mithun Vinod Shah, Hassan B. Alkhateeb, Aref Al‐Kali, Michelle A. Elliott, Kebede H. Begna, Alexandra P. Wolanskyj, Mark R. Litzow, William J. Hogan, Stephen M. Ansell, Animesh Pardanani, Ayalew Tefferi, Mrinal M. Patnaik
Abstract
Key Points Systemic immune microenvironment signatures in CMML indicate an altered T- and natural killer cell balance. CMML bone marrow dendritic cell aggregates associate with disease progression and systemic regulatory T-cell phenotypic switch.
Topics & Concepts
Chronic myelomonocytic leukemiaBone marrowImmune dysregulationImmune systemImmunologyDendritic cellBiologyMedicineCancer researchMyelodysplastic syndromesImmune Cell Function and InteractionAcute Myeloid Leukemia ResearchImmune cells in cancer