An oxidation responsive nano-radiosensitizer increases radiotherapy efficacy by remolding tumor vasculature
Xiaohui Wang, Xiaoyan Niu, Weizhou Sha, Xiaoyue Feng, Licheng Yu, Zhenjie Zhang, Wei Wang, Zhi Yuan
Abstract
, the perfusion unit (PU) increased by 78% after Au@SA-QBA treatment, and the coverage of pericytes increased by 32%, which in turn induced vascular normalization. In addition, blood routine and blood biochemical tests confirmed its good biocompatibility and 8HQ was not detected in the supernatant after homogenization of major organs. More importantly, after the synergistic treatment of vascular normalization and radiotherapy (4 Gy), the tumor growth inhibition rate was increased by 38.6% compared to the Au@SA-treated group with negligible side effects to normal tissues.
Topics & Concepts
RadiosensitizerRadiation therapyChemistryNano-Cancer researchPharmacologyMedicineInternal medicineMaterials scienceComposite materialNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingNanoparticle-Based Drug Delivery