Atroposelective carbonylation of aryl iodides with amides: facile synthesis of enantioenriched cyclic and acyclic amides
Liping Chen, Jiangfei Chen, Yujiao Zhang, Xingyi He, Ya‐Fei Han, Yuting Xiao, Gui‐Fen Lv, Xin Lü, Fan Teng, Qing Sun, Jin‐Heng Li
Abstract
An unprecedented palladium-catalyzed asymmetric carbonylation of ArI with carbon monoxide (CO) to expand a class of atroposelective cyclic and acyclic amides in good yields with high enantioselectivities has been reported.
Topics & Concepts
ChemistryCarbonylationArylCarbon monoxidePalladiumOrganic chemistryCombinatorial chemistryCatalysisAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityChemical synthesis and alkaloids