Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis
Wei‐Wei Haoyang, Qi Xiao, Zhongju Ye, Yonghong Fu, Dan‐Wei Zhang, Jian Li, Lehui Xiao, Zhan‐Ting Li, Jun‐Li Hou
Abstract
A series of glycoside-peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose-asialoglycoprotein receptor recognition.
Topics & Concepts
MoietyChemistryApoptosisIon channelPeptideGramicidinIonCancer cellBiophysicsCellBiochemistryCancerStereochemistryMembraneBiologyOrganic chemistryGeneticsReceptorIon channel regulation and functionMass Spectrometry Techniques and ApplicationsMolecular Sensors and Ion Detection